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Study finds higher levels of several toxic metals in children with autism

James Adams uatism research

James Adams, a professor of materials science and engineering, has done extensive research into autism. He directs the ASU Autism/Asperger’s Research Program. Photo: Jessica Slater/ASU

Posted February 25, 2013

In a recently published study in the journal Biological Trace Element Research, Arizona State University researchers report that children with autism had higher levels of several toxic metals in their blood and urine compared to typical children. The study involved 55 children with autism ages 5–16 years compared to 44 controls of similar age and gender.

The autism group had significantly higher levels of lead in their red blood cells (+41 percent) and significantly higher urinary levels of lead (+74 percent), thallium (+77 percent), tin (+115 percent), and tungsten (+44 percent). Lead, thallium, tin, and tungsten are toxic metals that can impair brain development and function, and also interfere with the normal functioning of other body organs and systems.

A statistical analysis was conducted to determine if the levels of toxic metals were associated with autism severity, using three different scales of autism severity. It was found that 38-47 percent of the variation of autism severity was associated with the level of several toxic metals, with cadmium and mercury being the most strongly associated.

In the paper about the study, the authors state “We hypothesize that reducing early exposure to toxic metals may help ameliorate symptoms of autism, and treatment to remove toxic metals may reduce symptoms of autism; these hypotheses need further exploration, as there is a growing body of research to support it.”

The study was led by James Adams, a President’s Professor in the School for Engineering of Matter, Transport and Energy, one of ASU’s Ira A. Fulton Schools of Engineering. He directs the ASU Autism/Asperger’s Research Program.

Adams previously published a study on the use of DMSA, an FDA-approved medication for removing toxic metals. The open-label study found that DMSA was generally safe and effective at removing some toxic metals. It also found that DMSA therapy improved some symptoms of autism. The biggest improvement was for children with the highest levels of toxic metals in their urine.

Overall, children with autism have higher average levels of several toxic metals, and levels of several toxic metals are strongly associated with variations in the severity of autism for all three of the autism severity scales investigated.

The study was funded by the Autism Research Institute and the Legacy Foundation.

Media Contact:
Joe Kullman, [email protected]
(480) 965-8122
Ira A. Fulton Schools of Engineering

 

About The Author

Joe Kullman

Joe Kullman is a science writer for the Ira A. Fulton Schools of Engineering. Before joining Arizona State University in 2006, Joe worked as a reporter, writer and editor for newspapers and magazines dating back to the dawn of the age of the personal computer. He began his career while earning degrees in journalism and philosophy from Kent State University in Ohio. Media Contact: [email protected] | 480-965-8122 | Ira A. Fulton Schools of Engineering Communications

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