A new approach has been created to create a chain of artificial genes according to the principle of “winner takes all”
The effectiveness of treatments for many diseases could be improved as a result of revelations from recent synthetic biology research at ASU. Xiaojun Tian, a Fulton Schools assistant professor of biomedical engineering, is the lead author of a report on research describing a new process for inserting synthetic gene chains into body cells. The links in those chains are designed to perform various functions, Tian says, but those links have to compete with each other for the limited cellular resources they need to perform their specific roles. The researchers have devised a way to insert individual gene chains into multiple host cells to enable the chains to work together without depleting the cells’ resources. The discovery has the potential to make cancer treatment more effective, researchers say.
See Also: Winner-take-all synthetic gene circuit opens new pathways to disease treatment, ASU News and SciTechDaily, February 8
New synthetic biology approach may improve delivery of programmable medicines, The Science Advisory Board, February 8